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(MEGA) of risk factors for venous thrombosis study.
From March 1999 through August 2004, investigators at six anticoagulation clinics enrolled patients with a first episode of venous thromboembolism, including deep vein thrombosis in the leg and pulmonary embolism.
The study included 2,471 patients and 3,534 matched controls ages 18 to 70. Information for the study was obtained from the patient self-reports, hospital records, and primary care physicians. The data collected included the most recent injury before the embolism and specifically addressed to minor injuries.
The investigators determined that 289 (11.7%) of the patients and 154 (4.4%) of the controls had sustained minor injuries in the preceding three months. After adjustment for age and sex, the between-group difference translated into an odds ratio of 3.1 for recent minor injury in the venous thromboembolism patients.
The difference was attributable entirely to minor injuries in the leg (OR: 5.1, 95% CI: 3.9 to 6.7). Minor injuries in other parts of the body had no association with thromboembolism.
Factor V Leiden carries with a minor leg injuries had a 50-fold increased risk of thromboembolism compared with noncarriers (OR: 49.7, 95% CI: 6.8 to 362.7).
Because clots were not associated with injuries in the areas of the body
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